The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its
historic popularity in drug design either as a pharmacophore or as a scaffold that projects …

The genomes of influenza viruses consist of multiple segments of single-stranded negative-
sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent …

Baloxavir acid (BXA), derived from the prodrug baloxavir marboxil (BXM), potently and
selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

The influenza virus polymerase transcribes or replicates the segmented RNA genome (viral
RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the …

Shorebirds and waterfowls are believed to be the reservoir hosts for influenza viruses,
whereas swine putatively act as mixing vessels. The recent identification of two influenza …

Highlights•Approval of first endonuclease inhibitor for influenza treatment.•Represents a
new class of influenza drug.•Single dose is clinically effective.For the first time in nearly 20 …

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …

Influenza virus is a segmented, negative strand RNA virus with each genome segment being
packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …