Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Background Emerging evidence indicates that inflammasome-induced inflammation plays a
crucial role in the pathogenesis of Parkinson's disease (PD). Several proteins including α …

Parkinson's disease (PD) is one of the most common degenerative brain disorders caused
by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and …

Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Background: Parkinson's disease (PD) is the second most common neurodegenerative
disease, and α-synuclein plays a critical role in the pathogenesis of PD. Studies have …

Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease (AD). Genetic predisposition and immune dysfunction are involved in …

The egress of α-synuclein in neuronally derived exosomes predates the clinical presentation
of Parkinson's disease (PD), offering a means of developing a predictive or prognostic test …

The aggregation of α-synuclein is a critical event in the pathogenesis of neurological
diseases, such as Parkinson or Alzheimer. Here, we present a label-free sensor based on …

Neurodegenerative disorders are characterised by progressive neuron loss in specific brain
areas. The most common are Alzheimer's disease and Parkinson's disease; in both cases …