Advances in proteomic and metabolomic profiling of neurodegenerative diseases

A Schumacher-Schuh, A Bieger, WV Borelli… - Frontiers in …, 2022 - frontiersin.org
Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …

[HTML][HTML] Plasma and serum alpha-synuclein as a biomarker in Parkinson's disease: a meta-analysis

M Zubelzu, T Morera-Herreras, G Irastorza… - Parkinsonism & related …, 2022 - Elsevier
Abstract Background Reliable biomarkers for Parkinson's disease (PD) diagnosis are
urgently needed. Alpha-synuclein (α-syn) and its proteoforms play a key role in PD …

Alpha synuclein post translational modifications: potential targets for Parkinson's disease therapy?

V Brembati, G Faustini, F Longhena… - Frontiers in molecular …, 2023 - frontiersin.org
Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …

Imaging protein aggregates in Parkinson's disease serum using aptamer-assisted single-molecule pull-down

YP Zhang, E Lobanova, D Emin, SV Lobanov… - Analytical …, 2023 - ACS Publications
The formation of soluble α-synuclein (α-syn) and amyloid-β (Aβ) aggregates is associated
with the development of Parkinson's disease (PD). Current methods mainly focus on the …

Whole body-electromyostimulation effects on serum biomarkers, physical performances and fatigue in Parkinson's patients: A randomized controlled trial

A di Cagno, A Buonsenso, M Centorbi… - Frontiers in Aging …, 2023 - frontiersin.org
Background Whole-body electromyostimulation (WB-EMS) was never previously applied to
Parkinson's disease (PD) patients. This randomized controlled study aimed to find the most …

Salivary alpha-synuclein as a biomarker for Parkinson's disease: a systematic review

A Bougea, C Koros, L Stefanis - Journal of Neural Transmission, 2019 - Springer
The search for a reliable, early-disease biomarker for Parkinson's disease (PD) that reflects
underlying pathology is a high priority in PD research. Salivary alpha-synuclein (α-Syn) is an …

Morphometry and stiffness of red blood cells—signatures of neurodegenerative diseases and aging

V Strijkova-Kenderova, S Todinova… - International journal of …, 2021 - mdpi.com
Human red blood cells (RBCs) are unique cells with the remarkable ability to deform, which
is crucial for their oxygen transport function, and which can be significantly altered under …

Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson's Disease

S Salaramoli, HR Joshaghani… - Neurology Research …, 2023 - Wiley Online Library
Finding reliable biomarkers has a crucial role in Parkinson's disease (PD) assessments.
Saliva is a bodily fluid, which might be used as a source of biomarkers for PD. Our article …

Plasma levels of α-synuclein, Aβ-40 and T-tau as biomarkers to predict cognitive impairment in Parkinson's disease

NC Chen, HL Chen, SH Li, YH Chang… - Frontiers in aging …, 2020 - frontiersin.org
Objective In this study, we assessed plasma biomarkers to identify cognitive impairment in
Parkinson's disease (PD) patients by applying ultra-sensitive immunomagnetic reduction …

Inflammation and Parkinson's disease pathogenesis: mechanisms and therapeutic insight

G Forloni, P La Vitola, M Cerovic, C Balducci - Progress in molecular …, 2021 - Elsevier
Abstract After Alzheimer's disease, Parkinson's disease is the most frequent
neurodegenerative disorder. Although numerous treatments have been developed to control …