Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …

The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins
through various chaperones and enzymes residing within the ER organelle. Perturbation in …

Obesity or excessive weight gain is identified as the most important and significant risk factor
in the development and progression of type 2 diabetes mellitus (DM) in all age groups. It has …

Contemporary scientists need no “p value” and “relative risk” statistics to be exquisitely
aware of the increasing prevalence of obesity and complications posed by obesity. It is now …

The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER),
due to genetic determinants and extrinsic environmental factors, leads to endoplasmic …

Two serious health conditions, obesity and atopic dermatitis (AD), share some pathological
features such as insulin resistance, leptin resistance and inflammation, and a growing body …

In recent decades, complex and exquisite pathways involved in the endoplasmic reticulum
(ER) and inflammatory stress responses have been demonstrated to participate in the …

The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …

Obesity is a global epidemic and overwhelming evidence indicates that it is a risk factor for
numerous cancers, including hepatocellular carcinoma (HCC), the third leading cause of …

Atherosclerosis refers to a unique form of chronic proinflammatory anomaly of the
vasculature, presented as rupture-prone or occlusive lesions in arteries. In advanced stages …