Modern synthetic methods for fluorine‐substituted target molecules

M Shimizu, T Hiyama - Angewandte Chemie International …, 2005 - Wiley Online Library
Fluorine has come to be recognized as a key element in materials science: in heat‐transfer
agents, liquid crystals, dyes, surfactants, plastics, elastomers, membranes, and other …

An evaluation of peptide‐bond isosteres

A Choudhary, RT Raines - ChemBioChem, 2011 - Wiley Online Library
Peptide‐bond isosteres can enable a deep interrogation of the structure and function of a
peptide or protein by amplifying or attenuating particular chemical properties. In this …

Palladium‐catalyzed difluoroalkylation of aryl boronic acids: a new method for the synthesis of aryldifluoromethylated phosphonates and carboxylic acid derivatives

Z Feng, QQ Min, YL Xiao, B Zhang… - Angewandte Chemie …, 2014 - Wiley Online Library
The palladium‐catalyzed difluoroalkylation of aryl boronic acids with
bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been …

Nickel‐Catalyzed Cross‐Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes

YL Xiao, WH Guo, GZ He, Q Pan… - Angewandte Chemie, 2014 - Wiley Online Library
Transition‐metal‐catalyzed difluoroalkylation of aromatics remains challenging despite the
importance of difluoroalkylated arenes in medicinal chemistry. Herein, the first successful …

Visible‐Light Photoredox‐Catalyzed C− H Difluoroalkylation of Hydrazones through an Aminyl Radical/Polar Mechanism

P Xu, G Wang, Y Zhu, W Li, Y Cheng… - Angewandte Chemie …, 2016 - Wiley Online Library
An unprecedented visible‐light‐induced direct C− H bond difluoroalkylation of aldehyde‐
derived hydrazones was developed. This reaction represents a new way to synthesize …

Exploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology

I Ojima - The Journal of organic chemistry, 2013 - ACS Publications
Over the last three decades, my engagement in “fluorine chemistry” has evolved
substantially because of the multidisciplinary nature of the research programs. I began my …

Highly Selective gem-Difluoroallylation of Organoborons with Bromodifluoromethylated Alkenes Catalyzed by Palladium

QQ Min, Z Yin, Z Feng, WH Guo… - Journal of the American …, 2014 - ACS Publications
A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3, 3-
difluoropropene (BDFP) in high efficiency with high α/γ-substitution regioselectivity has been …

Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

J Panda, BP Raiguru, M Mishra, S Mohapatra… - …, 2022 - Wiley Online Library
This review focuses on providing comprehensive highlights of the recent synthetic pathways
of imidazo [1, 2‐a] pyridines, assisted through transition metal‐catalyzed reactions, multi …

Copper‐Catalyzed 1,6‐Hydrodifluoroacetylation of para‐Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant

M Ke, Q Song - Advanced Synthesis & Catalysis, 2017 - Wiley Online Library
An original and efficient copper‐catalyzed 1, 6‐hydrodifluoroacetylation of para‐quinone
methides with difluoroalkyl bromides has been described with bis (pinacolato) diboron …

Moderne Synthesemethoden für fluorierte Verbindungen

M Shimizu, T Hiyama - Angewandte Chemie, 2005 - Wiley Online Library
Fluor hat sich zum Schlüsselelement in den Materialwissenschaften entwickelt: Fluorierte
Verbindungen dienen unter anderem als Wärmeüberträger, Flüssigkristalle, Farbstoffe …