Objectives In this review, the current biopharmaceutical approaches for evaluation of oral
formulation performance in paediatrics are discussed. Key findings The paediatric …

Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria
transmission in areas threatened by artemisinin resistance and areas aiming for malaria …

Developing medicines for children is now established in legislation in both the United States
and Europe; new drugs require pediatric study or investigation plans as part of their …

Information on the developmental changes in biliary excretion (BE) of drugs is sparse. The
aims of this study were to collate literature data on the pharmacokinetics of biliary excretion …

The emerging discipline of Quantitative Systems Pharmacology (QSP) enables the
integration of quantitative experimental data describing the interactions between the various …

The project SAFEPEDRUG aims to provide guidelines for drug research in children, based
on bottom-up and top-down approaches. Propofol, one of the studied model compounds …

Purpose To investigate the effect of OATP1B1 genotype as a covariate on repaglinide
pharmacokinetics and drug-drug interaction (DDIs) risk using a reduced physiologically …

This review summarizes various mathematical models of cell-autonomous mammalian
circadian clock. We present the basics necessary for understanding of the cell-autonomous …

Mathematical models are a core component in the foundation of cancer theory and have
been developed as clinical tools in precision medicine. Modeling studies for clinical …

The safety assessment of a flavour substance examines several factors, including metabolic
and physiological disposition data. The present article provides an overview of the …