Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Natural killer cells (NK) are innate lymphocytes endowed with the ability to recognize and kill
cancer cells. Consequently, adoptive transfer of autologous or allogeneic NK cells …

Tumour cell biomechanics has lately came to the fore as a disparate feature that fosters
cancer development and progression. Tumour mechanosensing entails a mechanical …

Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

Simple Summary Breast cancer is the most prevalent cancer in women worldwide, and it
exhibits a growing incidence. An increasing number of studies showed the complex …

In vitro three-dimensional models aim to reduce and replace animal testing and establish
new tools for oncology research and the development and testing of new anticancer …

The extracellular matrix (ECM) provides structural support for cells and mediates cell-stromal
communications. In addition to ECM proteins, mechanical force exerted from the ECM …

Although cancer is a genetic disease, physical changes such as stiffening of the
extracellular matrix also commonly occur in cancer. Cancer cells sense and respond to …

Circulating tumor cells (CTCs) acquire enhanced anti-anoikis abilities after experiencing
flow shear stress in the circulatory system. Our previous study demonstrated that low shear …