Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …

Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a
precipitous decline in renal function. In recent years, a growing body of studies have …

Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In
the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has …

In both humans and mice, repair of acute kidney injury is worse in males than in females.
Here, we provide evidence that this sexual dimorphism results from sex differences in …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …