Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …

Regeneration across tissues and organs exhibits significant variation throughout the body
and undergoes a progressive decline with age. To decode the relationships between aging …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent
among the elderly population. Urgent attention is required to prioritize preventive and …

Introduction An easily accessible and cost-free machine learning model based on prior
probabilities of vascular aging enables an application to pinpoint high-risk populations …

Background: Physical weakness and cardiovascular risk increase significantly with age, but
the underlying biological mechanisms remain largely unknown. This study aims to reveal the …

Background Increased arterial stiffness and low handgrip strength (HGS) are associated
with poor health outcomes and are a severe health risk for older adults. However, there is …

In human aging, liver aging per se not only increases susceptibility to liver diseases but also
increases vulnerability of other organs given its central role in regulating metabolism. Total …