The antiphospholipid syndrome causes venous, arterial, and small-vessel thrombosis;
pregnancy loss; and preterm delivery for patients with severe pre-eclampsia or placental …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Stay on the cutting edge with the newly revised eBook of Goldman's Cecil Medicine, with
over 400 updates personally selected by Dr. Lee Goldman and integrated directly into each …

This chapter about treatment for venous thromboembolic disease is part of the American
College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) …

The actual incidence of neurologic dysfunction resulting from hemorrhagic complications
associated with neuraxial blockade is unknown. Although the incidence cited in the literature …

Aims To evaluate apixaban single dose safety, tolerability, pharmacokinetics and
pharmacodynamics and assess the effect of food on apixaban pharmacokinetics. Methods A …

Background—The oral factor Xa inhibitor edoxaban has demonstrated safety and efficacy in
stroke prevention in patients with atrial fibrillation and in the treatment and secondary …

Appropriate tuning of binding selectivity is a primary objective in the discovery and
optimization of a compound on the path toward developing a drug. The environment in …

Background The first national recommendations on neuraxial anaesthesia and
antithrombotic drugs were published by the German Society for Anaesthesiology and …

For the past 60 years, oral vitamin K antagonists (eg, warfarin, acenocoumarol,
phenprocoumon, fluindione) have been widely prescribed. 5 However, their impact in …