Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic
system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which …

Dysregulation of the Wnt/β-catenin signaling pathway is strongly associated with various
aspects of cancer, including tumor initiation, proliferation, and metastasis as well as …

Vascular calcification is a major health risk and is highly correlated with atherosclerosis,
diabetes, and chronic kidney disease. The development of vascular calcification is an active …

Successfully targeting aberrant Wnt signaling in cancer, and even more so in chronic
diseases, requires a fine balancing act, wherein the 'dark side'of Wnt signaling in disease …

Background: Although cyclic AMP-response element binding protein-binding protein
(CBP)/β-catenin signaling is known to promote proliferation and fibrosis in various organ …

Simple Summary The coupling of metabolism with cellular status is critically important and
highly evolutionarily conserved. However, how cells coordinate metabolism with …

Simple Summary Given their high degree of identity and even greater similarity at the amino
acid level, Kat3 coactivators, CBP (Kat3A) and p300 (Kat3B), have long been considered …

Precision medicine emphasizes fine-grained diagnostics, taking individual variability into
account to enhance treatment effectiveness. Parkinson's disease (PD) heterogeneity among …

Methods Here, using scRNA-sequencing and ATAC-seq on primary chronic myelogenous
leukemia (CML) patient samples, combined with bioinformatics analyses, we further …