Mechanisms of deep brain stimulation
TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Cross-frequency coupling and intelligent neuromodulation
Cross-frequency coupling (CFC) reflects (nonlinear) interactions between signals of different
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …
frequencies. Evidence from both patient and healthy participant studies suggests that CFC …
[HTML][HTML] Dynamic network communication as a unifying neural basis for cognition, development, aging, and disease
Perception, cognition, and social interaction depend upon coordinated neural activity. This
coordination operates within noisy, overlapping, and distributed neural networks operating …
coordination operates within noisy, overlapping, and distributed neural networks operating …
[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor
Deep brain stimulation procedures offer an invaluable opportunity to study disease through
intracranial recordings from awake patients. Here, we address the relationship between …
intracranial recordings from awake patients. Here, we address the relationship between …
[HTML][HTML] Subthalamic nucleus phase–amplitude coupling correlates with motor impairment in Parkinson's disease
Objective High-amplitude beta band oscillations within the subthalamic nucleus are
frequently associated with Parkinson's disease but it is unclear how they might lead to motor …
frequently associated with Parkinson's disease but it is unclear how they might lead to motor …
Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation
The subthalamic nucleus (STN) supports action selection by inhibiting all motor programs
except the desired one. Recent evidence suggests that STN can also cancel an already …
except the desired one. Recent evidence suggests that STN can also cancel an already …
[HTML][HTML] Adaptive deep brain stimulation in Parkinson's disease
Abstract Although Deep Brain Stimulation (DBS) is an established treatment for Parkinson's
disease (PD), there are still limitations in terms of effectivity, side-effects and battery …
disease (PD), there are still limitations in terms of effectivity, side-effects and battery …
Npas1+ pallidal neurons target striatal projection neurons
KE Glajch, DA Kelver, DJ Hegeman, Q Cui… - Journal of …, 2016 - Soc Neuroscience
Compelling evidence demonstrates that the external globus pallidus (GPe) plays a key role
in processing sensorimotor information. An anatomical projection from the GPe to the dorsal …
in processing sensorimotor information. An anatomical projection from the GPe to the dorsal …
[HTML][HTML] Evoked potentials reveal neural circuits engaged by human deep brain stimulation
Background Deep brain stimulation (DBS) is an effective therapy for reducing the motor
symptoms of Parkinson's disease, but the mechanisms of action of DBS and neural …
symptoms of Parkinson's disease, but the mechanisms of action of DBS and neural …