To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Organoid technology provides a revolutionary paradigm toward therapy but has yet to be
applied in humans, mainly because of reproducibility and scalability challenges. Here, we …

The sinoatrial node (SAN) is the primary pacemaker of the heart and controls heart rate
throughout life. Failure of SAN function due to congenital disease or aging results in slowing …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Human pluripotent stem cells (hPSCs) represent a renewable source of pancreatic beta
cells for both basic research and therapeutic applications. Given this outstanding potential …

Twenty years after the initial description of a tissue engineered construct, 3-dimensional
human cardiac tissues of different kinds are now generated routinely in many laboratories …