Genetic associations between autoimmune diseases and the risks of severe sepsis and 28-day mortality: a two-sample Mendelian randomization study
X Tie, Y Zhao, J Su, X Liu, T Zou, W Yin - Frontiers in Medicine, 2024 - frontiersin.org
Background Autoimmune diseases exhibit heterogenous dysregulation of pro-inflammatory
or anti-inflammatory cytokine expression, akin to the pathophysiology of sepsis. It is …
or anti-inflammatory cytokine expression, akin to the pathophysiology of sepsis. It is …
[HTML][HTML] Discovery of novel 2, 3, 5-trisubstituted pyridine analogs as potent inhibitors of IL-1β via modulation of the p38 MAPK signaling pathway
E Carrasco, P Gomez-Gutierrez, PM Campos… - European journal of …, 2021 - Elsevier
Interleukin-1β is a central mediator of innate immune responses and inflammation. It plays a
key role in a wide variety of pathologies, ranging from autoinflammatory diseases to …
key role in a wide variety of pathologies, ranging from autoinflammatory diseases to …
[HTML][HTML] Regulation of the AGEs-induced inflammatory response in human periodontal ligament cells via the AMPK/NF-κB/NLRP3 signaling pathway
ZL Guo, J Zhou, XJ Lin, Q Yuan, YL Dong… - Experimental Cell …, 2024 - Elsevier
The heightened prevalence and accelerated progression of periodontitis in individuals with
diabetes is primarily attributed to inflammatory responses in human periodontal ligament …
diabetes is primarily attributed to inflammatory responses in human periodontal ligament …
[HTML][HTML] Implications of Ocular Confounding Factors for Aqueous Humor Proteomic and Metabolomic Analyses in Retinal Diseases
B Titz, J Siebourg-Polster, F Bartolo… - … vision science & …, 2024 - iovs.arvojournals.org
Purpose: To assess the impact of ocular confounding factors on aqueous humor (AH)
proteomic and metabolomic analyses for retinal disease characterization. Methods: This …
proteomic and metabolomic analyses for retinal disease characterization. Methods: This …
[HTML][HTML] 生物制剂在白塞综合征中的治疗进展
鲍华芳， 管剑龙 - 复旦学报(医学版), 2022 - jms.fudan.edu.cn
白塞综合征(Behçet's syndrome, BS) 机制不明, 多系统损害及内脏受累患者预后差. α
干扰素和单克隆抗肿瘤坏死因子α 抗体可以改善内脏受累BS 患者的预后 …
干扰素和单克隆抗肿瘤坏死因子α 抗体可以改善内脏受累BS 患者的预后 …
Macrophage inhibitory factor alters the functionality of macrophages and their involvement in disease pathogenesis of active generalized vitiligo patients
N Sain, V Hooda, A Singh, S Gupta, S Arava, A Sharma - Cytokine, 2024 - Elsevier
Introduction In autoimmune dermatitis patients, a macrophage migration inhibitory factor
(MIF) is widely used to determine the severity of the diseases with other clinical parameters …
(MIF) is widely used to determine the severity of the diseases with other clinical parameters …
心房颤动病人IL-1β, Calpain-2 水平与心脏结构重构的相关性研究
卢园园， 李浩宇， 耿嘉逸， 雷思思， 刘晨阳… - 蚌埠医学院 …, 2023 - xuebao.bbmc.edu.cn
目的探讨心房颤动(房颤) 病人血清中白细胞介素-1β (IL-1β), 钙蛋白酶-2 (Calpain-2)
表达水平及与心脏结构重构的相关性. 方法选取确诊为房颤的病人150 例为观察组, 依据2020 …
表达水平及与心脏结构重构的相关性. 方法选取确诊为房颤的病人150 例为观察组, 依据2020 …
Potential therapeutic strategies in chronic inflammatory demyelinating polyradiculoneuropathy
J Hu, C Zhao, J Lin - Autoimmunity Reviews, 2022 - Elsevier
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune
neuropathy involving peripheral nerve and nerve roots. The pathological hallmark of CIDP is …
neuropathy involving peripheral nerve and nerve roots. The pathological hallmark of CIDP is …
Aging considerations of cytokines (IL-18, IL-36α, IL-37, and IL-38) associated with rheumatoid arthritis
NS Abdul-Sahib, MM Mahmood… - Egyptian Journal of Basic …, 2024 - Taylor & Francis
The pro-inflammatory cytokines IL-18 and IL-36α and the anti-inflammatory cytokines IL-37
and IL-38 are proposed to have a pathophysiological role in rheumatoid arthritis (RA) …
and IL-38 are proposed to have a pathophysiological role in rheumatoid arthritis (RA) …
The 5'untranslated region variant rs3811050 C/T of the interleukin-38 encoding gene is associated with susceptibility to rheumatoid arthritis in Iraqi women
DFN Bani-Wais, AH Ad'hiah - Molecular Biology Reports, 2024 - Springer
Abstract Background Interleukin (IL)-38, the latest member of the IL-1 cytokine family, is
proposed to have a pathogenic role in rheumatoid arthritis (RA). It is encoded by the IL1F10 …
proposed to have a pathogenic role in rheumatoid arthritis (RA). It is encoded by the IL1F10 …