GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors
AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …
scale genome-wide association studies (GWASs) recently discovered and cross-validated …
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker… - Nature …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …
Genetics of substance use disorders in the era of big data
J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Posttraumatic stress disorder and cardiovascular disease: state of the science, knowledge gaps, and research opportunities
CJ O'Donnell, LS Longacre, BE Cohen… - JAMA …, 2021 - jamanetwork.com
Posttraumatic stress disorder (PTSD) is characterized by a persistent maladaptive reaction
after exposure to severe psychological trauma. Traumatic events that may precipitate PTSD …
after exposure to severe psychological trauma. Traumatic events that may precipitate PTSD …
[图书][B] The psychology of religion: An empirical approach
RW Hood Jr, PC Hill, B Spilka - 2009 - books.google.com
Scholarly and comprehensive yet accessible, this state-of-the-science work is widely
regarded as the definitive graduate-level psychology of religion text. The authors synthesize …
regarded as the definitive graduate-level psychology of religion text. The authors synthesize …
A concerted neuron–astrocyte program declines in ageing and schizophrenia
E Ling, J Nemesh, M Goldman, N Kamitaki, N Reed… - Nature, 2024 - nature.com
Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …
cellular terms. Here we describe a relationship between people's cortical neurons and …
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci
NA Kimbrel, AE Ashley-Koch, XJ Qin, JH Lindquist… - Molecular …, 2022 - nature.com
To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder
BACKGROUND Major depressive disorder (MDD) and posttraumatic stress disorder (PTSD)
are highly comorbid and exhibit strong correlations with one another. We aimed to …
are highly comorbid and exhibit strong correlations with one another. We aimed to …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …