A principal component approach to improve association testing with polygenic risk scores
Polygenic risk scores (PRSs) have become an increasingly popular approach for
demonstrating polygenic influences on complex traits and for establishing common …
demonstrating polygenic influences on complex traits and for establishing common …
Identification of novel, replicable genetic risk loci for suicidal thoughts and behaviors among US military veterans
NA Kimbrel, AE Ashley-Koch, XJ Qin… - JAMA …, 2023 - jamanetwork.com
Importance Suicide is a leading cause of death; however, the molecular genetic basis of
suicidal thoughts and behaviors (SITB) remains unknown. Objective To identify novel …
suicidal thoughts and behaviors (SITB) remains unknown. Objective To identify novel …
A decennial review of psychotraumatology: what did we learn and where are we going?
On 6 December 2019 we start the 10th year of the European Journal of Psychotraumatogy
(EJPT), a full Open Access journal on psychotrauma. This editorial is part of a special issue …
(EJPT), a full Open Access journal on psychotrauma. This editorial is part of a special issue …
Translating across circuits and genetics toward progress in fear-and anxiety-related disorders
KJ Ressler - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Anxiety and fear-related disorders are common and disabling, and they significantly
increase risk for suicide and other causes of morbidity and mortality. However, there is …
increase risk for suicide and other causes of morbidity and mortality. However, there is …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …
shifting clinical phenomena across the life span. We investigated the convergence of …
Pervasive downward bias in estimates of liability-scale heritability in genome-wide association study meta-analysis: a simple solution
Background Single nucleotide polymorphism–based heritability is a fundamental quantity in
the genetic analysis of complex traits. For case-control phenotypes, for which the continuous …
the genetic analysis of complex traits. For case-control phenotypes, for which the continuous …
Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy
Although large genome-wide association studies (GWAS) of major depressive disorder
(MDD) have identified many significant loci, the SNP-based heritability remains notably low …
(MDD) have identified many significant loci, the SNP-based heritability remains notably low …
Leveraging large-scale genetics of PTSD and cardiovascular disease to demonstrate robust shared risk and improve risk prediction accuracy
AV Seligowski, B Misganaw, LA Duffy… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Individuals with posttraumatic stress disorder (PTSD) are significantly more likely
to be diagnosed with cardiovascular disease (CVD)(eg, myocardial infarction, stroke). The …
to be diagnosed with cardiovascular disease (CVD)(eg, myocardial infarction, stroke). The …
Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects
Trauma and chronic stress exposure are the strongest predictors of lifetime neuropsychiatric
disease presentation. These disorders often have significant sex biases, with females …
disease presentation. These disorders often have significant sex biases, with females …
Genetically predicted education attainment in relation to somatic and mental health
A deeper understanding of the causal links from education level to health outcomes may
shed a light for disease prevention. In the present Mendelian randomization study, we found …
shed a light for disease prevention. In the present Mendelian randomization study, we found …