Sex-based contributors to and consequences of post-traumatic stress disorder
Abstract Purpose of Review Women are twice as likely to develop post-traumatic stress
disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini …
disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini …
[HTML][HTML] Enhancing discovery of genetic variants for posttraumatic stress disorder through integration of quantitative phenotypes and trauma exposure information
Background Posttraumatic stress disorder (PTSD) is heritable and a potential consequence
of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD …
of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD …
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder
UK Biobank (UKB) is a key contributor in mental health genome-wide association studies
(GWAS) but only~ 31% of participants completed the Mental Health Questionnaire (“MHQ …
(GWAS) but only~ 31% of participants completed the Mental Health Questionnaire (“MHQ …
Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study
X Yang, L Yang, T Zhang, H Zhang, H Chen… - Frontiers in …, 2023 - frontiersin.org
Background The brain-gut axis link has attracted increasing attention, with observational
studies suggesting that the relationship between common mental disorders and …
studies suggesting that the relationship between common mental disorders and …
Genomic influences on self-reported childhood maltreatment
Childhood maltreatment is highly prevalent and serves as a risk factor for mental and
physical disorders. Self-reported childhood maltreatment appears heritable, but the specific …
physical disorders. Self-reported childhood maltreatment appears heritable, but the specific …
Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder
Genome-wide association studies (GWAS) have identified several risk loci for post-traumatic
stress disorder (PTSD); however, how they confer PTSD risk remains unclear. We aimed to …
stress disorder (PTSD); however, how they confer PTSD risk remains unclear. We aimed to …
Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder
Background Epigenetic mechanisms have been suggested to play a role in the development
of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data …
of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data …
Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint
M Ikeda, T Saito, T Kanazawa, N Iwata - Journal of Human Genetics, 2021 - nature.com
Genome-wide association studies (GWASs) have detected many susceptible variants for
common diseases, including psychiatric disorders. However, because of the small effect size …
common diseases, including psychiatric disorders. However, because of the small effect size …
Circulating proteins influencing psychiatric disease: A Mendelian randomization study
Background There is a pressing need for novel drug targets for psychiatric disorders.
Circulating proteins are potential candidates because they are relatively easy to measure …
Circulating proteins are potential candidates because they are relatively easy to measure …
Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights
Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …