Altered fear behavior in aeroallergen house dust mite exposed C57Bl/6 mice: A model of Th2-skewed airway inflammation

E Allgire, RA Ahlbrand, N Nawreen, A Ajmani… - Neuroscience, 2023 - Elsevier
There is a growing interest for studying the impact of chronic inflammation, particularly lung
inflammation, on the brain and behavior. This includes asthma, a chronic inflammatory …

PTSD: past, present and future implications for China

YG Zhou, ZL Shang, F Zhang, LL Wu… - Chinese Journal of …, 2021 - mednexus.org
There has been a long history since human beings began to realize the existence of post-
traumatic symptoms. Posttraumatic stress disorder (PTSD), a diagnostic category adopted in …

Posttraumatic stress disorder and breast cancer: Risk factors and the role of inflammation and endocrine function

LC Brown, AR Murphy, CS Lalonde, PD Subhedar… - Cancer, 2020 - Wiley Online Library
A breast cancer diagnosis can be a life‐changing and stressful experience that can lead to
chronic mental health conditions such as posttraumatic stress disorder (PTSD). Greater than …

Mendelian randomization analyses identify bidirectional causal relationships of obesity with psychiatric disorders

W Chen, J Feng, S Jiang, J Guo, XL Zhang… - Journal of Affective …, 2023 - Elsevier
Background Obesity have been showed to be strongly associated with psychiatric disorders,
but the exact causality and the direction of the relationship remain inconclusive. Thus, we …

The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness

WR Reay, MP Geaghan, MJ Cairns - Nature communications, 2022 - nature.com
Pneumonia remains one of the leading causes of death worldwide. In this study, we use
genome-wide meta-analysis of lifetime pneumonia diagnosis (N= 391,044) to identify four …

Shared genetic links between frontotemporal dementia and psychiatric disorders

C Li, D Pang, J Lin, T Yang, H Shang - BMC medicine, 2022 - Springer
Background Epidemiological and clinical studies have suggested comorbidity between
frontotemporal dementia (FTD) and psychiatric disorders. FTD patients carrying specific …

Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients

L Stertz, J Di Re, G Pei, GR Fries, E Mendez… - …, 2021 - nature.com
Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular
models of psychiatric disorders that account for a patient's genetic background. Here, we …

Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood

NP Daskalakis, A Iatrou, C Chatzinakos, A Jajoo… - Science, 2024 - science.org
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion,
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …

Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males

R Yang, A Gautam, D Getnet, BJ Daigle, S Miller… - Molecular …, 2021 - nature.com
Post-traumatic stress disorder (PTSD) is a heterogeneous condition evidenced by the
absence of objective physiological measurements applicable to all who meet the criteria for …

Heterogeneity and polygenicity in psychiatric disorders: a genome-wide perspective

FR Wendt, GA Pathak, DS Tylee, A Goswami… - Chronic …, 2020 - journals.sagepub.com
Genome-wide association studies (GWAS) have been performed for many psychiatric
disorders and revealed a complex polygenic architecture linking mental and physical health …