Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins

AJ Shah, V Vaccarino, J Goldberg, M Huang… - JAMA Network …, 2024 - jamanetwork.com
Importance Obstructive sleep apnea (OSA) is a common condition in older adult (aged> 65
years) populations, but more mechanistic research is needed to individualize treatments …

Stability of polygenic scores across discovery genome-wide association studies

LM Schultz, AK Merikangas, K Ruparel… - Human Genetics and …, 2022 - cell.com
Polygenic scores (PGS) are commonly evaluated in terms of their predictive accuracy at the
population level by the proportion of phenotypic variance they explain. To be useful for …

Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder

G Sudre, DE Gildea, GG Shastri, W Sharp, B Jung… - Molecular …, 2023 - nature.com
Despite advances in identifying rare and common genetic variants conferring risk for ADHD,
the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a …

Assessment of posttraumatic stress disorder and educational achievement in Sweden

A Vilaplana-Pérez, A Sidorchuk, A Pérez-Vigil… - JAMA network …, 2020 - jamanetwork.com
Importance Posttraumatic stress disorder (PTSD) has been associated with impaired
educational performance. Previous studies on the disorder could not control for important …

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

C Okhuijsen-Pfeifer, MZ van der Horst… - Translational …, 2022 - nature.com
Clozapine is the most effective antipsychotic for patients with treatment-resistant
schizophrenia. However, response is highly variable and possible genetic underpinnings of …

Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non‐perinatal depression

J Kiewa, S Meltzer‐Brody, J Milgrom… - Depression and …, 2022 - Wiley Online Library
Background Distinctions between major depressive disorder (MDD) and perinatal
depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to …

Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support

C Muniz Carvalho, FR Wendt, AX Maihofer… - …, 2021 - nature.com
Inflammatory markers like C-reactive protein (CRP) have been associated with post-
traumatic stress disorder (PTSD) and traumatic experiences, but the underlying mechanisms …

The structure of psychiatric comorbidity without selection and assortative mating

Z Ayorech, FA Torvik, R Cheesman… - Translational …, 2024 - nature.com
The widespread comorbidity observed across psychiatric disorders may be the result of
processes such as assortative mating, gene-environment correlation, or selection into …

Prevalence and characterization of psychological trauma in patients with fibromyalgia: A cross‐sectional study

I Gardoki-Souto, D Redolar-Ripoll… - Pain Research and …, 2022 - Wiley Online Library
Background. Preliminary evidence suggests that psychological trauma, especially childhood
trauma, is a risk factor for the onset of fibromyalgia (FM). Objective. The main objective of this …

Gender issues in PTSD

R Kimerling, P Ouimette… - Handbook of PTSD …, 2007 - books.google.com
Effective research and treatment of posttraumatic stress disorder (PTSD) requires attention
to gender issues regarding trauma exposure, traumatic stress reactions, and treatment of …