Individual differences in self-control predict many health and life outcomes. Building on twin
literature, we used genomic structural equation modeling to test the hypothesis that genetic …

Pain often occurs in parallel with neuropsychiatric disorders. However, the underlying
mechanisms and potential causality have not been well studied. We collected the genome …

Biomarkers that predict symptom trajectories after trauma can facilitate early detection or
intervention for posttraumatic stress disorder (PTSD) and may also advance our …

Post-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and
under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid …

The molecular mechanisms underlying posttraumatic stress disorder (PTSD) are yet to be
fully elucidated, especially in underrepresented population groups. Expression quantitative …

Background Early stress increases the risk for psychiatric disorders. Glucocorticoids are
stress mediators that regulate transcriptional activity and morphology in the hippocampus …

Polygenic risk scores (PRS) based on European training data suffer reduced accuracy in
non-European target populations, exacerbating health disparities. This loss of accuracy …

Exposure to traumatic stress can lead to fear dysregulation, which has been associated with
posttraumatic stress disorder (PTSD). Previous work showed that a polymorphism in the …

Genome-wide association studies have identified 10q24. 32 as a robust schizophrenia risk
locus. Here we identify a regulatory variant (rs10786700) that disrupts binding of …

Systemic lupus erythematosus (SLE) is a heterogeneous, multisystem autoimmune disorder
characterized by unpredictable disease flares. Although the pathogenesis of SLE is …