Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment

W Li, Q Liu, J Shi, X Xu, J Xu - Frontiers in Immunology, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional
differentiation potential and strong immunomodulatory capacity. MSCs have been widely …

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Q Xu, Q Fu, Z Li, H Liu, Y Wang, X Lin, R He… - Nature …, 2021 - nature.com
Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …

Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis

D Lu, Y Xu, Q Liu, Q Zhang - Frontiers in cell and developmental …, 2021 - frontiersin.org
Macrophages are involved in almost every aspect of biological systems and include
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …

Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury

X Li, Y Guan, C Li, T Zhang, F Meng, J Zhang… - Stem Cell Research & …, 2022 - Springer
Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries
(PNI), and coordination of the local inflammatory response is of great significance for the …

Adipose tissue macrophage polarization in healthy and unhealthy obesity

AD Ruggiero, CCC Key, K Kavanagh - Frontiers in nutrition, 2021 - frontiersin.org
Over 650 million adults are obese (body mass index≥ 30 kg/m2) worldwide. Obesity is
commonly associated with several comorbidities, including cardiovascular disease and type …

[HTML][HTML] Sialic acid-targeted cyclodextrin-based nanoparticles deliver CSF-1R siRNA and reprogram tumour-associated macrophages for immunotherapy of prostate …

Y Sun, MF Cronin, MCP Mendonca, J Guo… - European Journal of …, 2023 - Elsevier
Prostate cancer remains a serious condition threatening the health of men. Due to the
complicated nature of the tumour microenvironment (TME), conventional treatments face …

Biomaterial-assisted macrophage cell therapy for regenerative medicine

S Sung, LA Steele, GE Risser, KL Spiller - Advanced drug delivery reviews, 2023 - Elsevier
Although most tissue types are capable of some form of self-repair and regeneration, injuries
that are larger than a critical threshold or those occurring in the setting of certain diseases …

Role of mesenchymal stem cells and their paracrine mediators in macrophage polarization: an approach to reduce inflammation in osteoarthritis

SS Kuppa, HK Kim, JY Kang, SC Lee… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …

Versatile hydrogel Dressings that dynamically regulate the Healing of Infected Deep burn wounds

S Wang, S Wu, Y Yang, J Zhang… - Advanced …, 2023 - Wiley Online Library
Severe burns threaten patient lives due to pain, inflammation, bacterial infection, and
scarring. Most burn dressings that are commonly used perform a single function and are not …