Low and oscillatory wall shear stress is widely assumed to play a key role in the initiation
and development of atherosclerosis. Indeed, some studies have relied on the low shear …

We hypothesize that the plasma cholesterol and LDL levels currently considered normal are
evolutionarily too high. Cholesterol and/or oxidized low-density lipoprotein, even as a mild …

Mechanical overload can be classified into pressure overload and volume overload, causing
concentric and eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate …

Objective—The mechanisms promoting the focal formation of rupture-prone coronary
plaques in vivo remain incompletely understood. This study tested the hypothesis that …

Over the past decade, non-invasive preclinical imaging has emerged as an important tool to
facilitate biomedical discovery. Not only have the markets for these tools accelerated, but the …

Objective—To understand the anatomy and physiology of ascending aortic aneurysms in
angiotensin II–infused ApoE−/− mice. Approach and Results—We combined an extensive in …

Following surgical induction of aortic valve regurgitation (AR), extensive atherosclerotic
plaque development along the descending thoracic and abdominal aorta of Ldlr−/− mice …

Atherosclerosis is a chronic inflammatory disease of the arterial tree that develops at
predisposed sites, coinciding with locations that are exposed to low or oscillating shear …

The last decade has seen tremendous growth in the use of computational methods for
simulating large artery hemodynamics. As computational models become more …

Mice are widely used to investigate atherogenesis, which is known to be influenced by
stresses related to blood flow. However, numerical characterization of the haemodynamic …