The prosurvival activity of phosphoinositide 3 kinase (PI3K)/Akt (also known as protein
kinase B, PKB) pathway has been investigated in great detail in human physiology and …

Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …

Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand
breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and …

Cancer is fueled by deregulation of signaling pathways in control of cellular growth and
proliferation. These pathways are also targeted by infectious pathogens en route to …

Abstract Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions
and development. However, its role in cancer is less well understood. Here, we show that …

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem
cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor …

Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …

Prostate cancer (PCa) is the most commonly diagnosed noncutaneous malignancy and
second leading cause of cancer-related deaths in US males. Clinically, locally confined …

Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by
regulating chromatin structure and is indispensable for self-renewal of both normal and …

Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial
developmental and physiological processes in the cell. More recently, they have been found …