Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines

MI Malkov, CT Lee, CT Taylor - Cells, 2021 - mdpi.com
Hypoxia and inflammation are frequently co-incidental features of the tissue
microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on …

Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence

B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

LncTar: a tool for predicting the RNA targets of long noncoding RNAs

J Li, W Ma, P Zeng, J Wang, B Geng… - Briefings in …, 2015 - academic.oup.com
Long noncoding RNAs (lncRNAs) represent a big category of noncoding RNA molecules,
and increasing studies have shown that they play important roles in various critical …

HIF2-induced long noncoding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis

Y Niu, L Bao, Y Chen, C Wang, M Luo, B Zhang… - Cancer research, 2020 - AACR
Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but
their biological functions remain largely unknown. Here, we identified a hitherto …

Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

S Müller, S Raulefs, P Bruns, F Afonso-Grunz… - Molecular cancer, 2015 - Springer
Background Previous studies identified microRNAs (miRNAs) and messenger RNAs with
significantly different expression between normal pancreas and pancreatic cancer (PDAC) …

Long non-coding RNAs and cervical cancer

H Aalijahan, S Ghorbian - Experimental and molecular pathology, 2019 - Elsevier
Cervical cancer is determined as the second highest number of deaths factor in female
cancers. Here is a need to find new biomarkers for detection and preliminary prognosis …

Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21

P Wang, Y Liu, Y Yao, Z Li, Z Li, J Ma, Y Xue - Cellular signalling, 2015 - Elsevier
Long non-coding RNAs (lncRNAs) are aberrantly expressed in many diseases including
cancer. LncRNA CASC2 (cancer susceptibility candidate 2) has been characterized as a …

Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21

L Hu, H Ye, G Huang, F Luo, Y Liu, Y Liu, X Yang… - Tumor Biology, 2016 - Springer
Long noncoding RNAs (lncRNAs) are aberrantly expressed in various cancers. Although
lncRNA GAS5 (growth arrest-specific transcript 5) has been characterized as a tumor …

Precision medicine and driver mutations: computational methods, functional assays and conformational principles for interpreting cancer drivers

R Nussinov, H Jang, CJ Tsai… - PLoS computational …, 2019 - journals.plos.org
At the root of the so-called precision medicine or precision oncology, which is our focus
here, is the hypothesis that cancer treatment would be considerably better if therapies were …

Oncocers: ceRNA-mediated cross-talk by sponging miRNAs in oncogenic pathways

S Ergun, S Oztuzcu - Tumor Biology, 2015 - Springer
Competing endogenous RNAs (ceRNAs) are RNA transcripts which can communicate with
each other by decreasing targeting concentration of micro-RNA (miRNA) with the …