In various systemic disorders, structural changes in the microenvironment of diseased
tissues enable both passive and active targeting of therapeutic agents to these tissues. This …

We evaluated how different degrees of air pollution affect the ocular surface of a cohort of
human subjects in Beijing by correlating in-patient test outcomes with tear cytokines. A cross …

Objective Lumbar facet joint degeneration (FJD) may be an important cause of low back
pain (LBP) and sciatica. The goal of this study was to characterize cellular alterations of …

Background Women, and those older than 65 years of age, are particularly susceptible to
dry eye disorders (DEDs). Inflammation is clearly involved in the pathogenesis of DEDs, and …

Introduction: Angiogenesis was first proposed as a possible target for the treatment of
human cancer several decades ago. During recent years, the discovery of VEGF as the main …

Objective CD248 is a transmembrane glycoprotein expressed on the surface of activated
perivascular and fibroblast‐like cells. This study was undertaken to explore the function of …

Crohn's disease and ulcerative colitis are both associated with an increased risk of
inflammation-associated colorectal carcinoma. Colitis-associated cancer (CAC) is one of the …

Preeclampsia is a low-grade systemic inflammatory condition in which oxidative stress and
endothelial dysfunction occurs. Plasma levels of soluble receptor for vascular endothelial …

The erythroid differentiation regulator 1 (Erdr1), which is a novel and highly conserved
factor, was recently reported to be negatively regulated by IL‐18 and to play a crucial role as …

Ocular neovascularisation is a pathological hallmark of some forms of debilitating blindness
including diabetic retinopathy, age related macular degeneration and retinopathy of …