[HTML][HTML] Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines

S Marquez-Martinez, A Vijayan, S Khan… - Current Opinion in …, 2023 - Elsevier
Highlights•Adenoviruses display broad tropism due to use of ubiquitous cell surface
receptors.•Modifications to capsid proteins or genomic regions alter innate immune …

Recent advances in the development of adenovirus-vectored vaccines for parasitic infections

C Koger-Pease, DJ Perera, M Ndao - Pharmaceuticals, 2023 - mdpi.com
Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …

Memory T cells: promising biomarkers for evaluating protection and vaccine efficacy against leishmaniasis

M Nateghi-Rostami, Y Sohrabi - Frontiers in Immunology, 2024 - frontiersin.org
Understanding the immune response to Leishmania infection and identifying biomarkers
that correlate with protection are crucial for developing effective vaccines. One intriguing …

Leishmaniasis vaccines: applications of RNA technology and targeted clinical trial designs

MS Duthie, BAS Machado, R Badaró, PM Kaye… - Pathogens, 2022 - mdpi.com
Leishmania parasites cause a variety of discrete clinical diseases that present in regions
where their specific sand fly vectors sustain transmission. Clinical and laboratory research …

Precision Medicine in Control of Visceral Leishmaniasis Caused by L. donovani

EE Zijlstra - Frontiers in Cellular and Infection Microbiology, 2021 - frontiersin.org
Precision medicine and precision global health in visceral leishmaniasis (VL) have not yet
been described and could take into account how all known determinants improve …

Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the …

S Singh-Phulgenda, R Kumar, P Dahal… - PLOS Neglected …, 2024 - journals.plos.org
Background Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis which can occur
after successful treatment of visceral leishmaniasis (VL) and is a public health problem in VL …

[HTML][HTML] LEISH2b-A phase 2b study to assess the safety, efficacy, and immunogenicity of the Leishmania vaccine ChAd63-KH in post-kala azar dermal leishmaniasis

C Lacey, A Musa, B Younis, M Osman… - Wellcome Open …, 2022 - ncbi.nlm.nih.gov
Background: The leishmaniases are neglected tropical diseases caused by various
Leishmania parasite species transmitted by sand flies. They comprise a number of systemic …

Deciphering the Intricate Dynamics of Inflammasome Regulation in Visceral and Post-Kala-Azar Dermal Leishmaniasis: A Meta-Analysis of Consistencies

S Bhattacharya, S Chakraborty, D Manna, P Thakur… - Acta Tropica, 2024 - Elsevier
Post Kala-azar dermal leishmaniasis (PKDL) arises as a significant dermal sequel following
Visceral leishmaniasis (VL) caused by protozoan parasite Leishmania donovani (LD). PKDL …

[PDF][PDF] Vaccine development for human leishmaniasis

M de Carvalho Clímaco, L Kraemer… - Vaccines for Neglected …, 2023 - library.oapen.org
The development of vaccines for human leishmaniasis is one of the most important
approaches for effectively controlling and/or eradicating the several forms of the disease …

Semantic rule Web-based Diagnosis and Treatment of Vector-Borne Diseases using SWRL rules

R Chandra, S Tiwari, S Agarwal, N Singh - arXiv preprint arXiv …, 2023 - arxiv.org
Vector-borne diseases (VBDs) are a kind of infection caused through the transmission of
vectors generated by the bites of infected parasites, bacteria, and viruses, such as ticks …