Organismal aging is normally accompanied by an increase in the number of senescent cells,
growth-arrested metabolic active cells that affect normal tissue function. These cells present …

Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …

Eukaryotic translation initiation factor 4E–binding protein 1 (4E-BP1) is a key downstream
effector of mTOR complex 1 (mTORC1) that represses cap-dependent mRNA translation …

Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here …

Frailty is a still-evolving concept of a complex phenomenon. There are several algorithms
and strategies for assessing frailty syndrome, but currently, no universally accepted …

Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass
and function. This disorder has been associated with a range of adverse health outcomes …

The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of
transcription factors. FOXO proteins were originally identified as regulators of insulin-related …

Although adult skeletal muscle is composed of fully differentiated fibers, it retains the
capacity to regenerate in response to injury and to modify its contractile and metabolic …

Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including
exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …