Sarcopenia, the age-related loss of skeletal muscle mass and function, is becoming more
prevalent as the lifespan continues to increase in most populations. As sarcopenia is highly …

Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including
exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal …

Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass
and quality, decreased power and strength, increased risk of injury from falls, and often …

The prolongation of skeletal muscle strength in aging and neuromuscular disease has been
the objective of numerous studies employing a variety of approaches. It is generally …

Sarcopenia is the loss of both muscle mass and function with age. Although the molecular
underpinnings of sarcopenia are not fully understood, numerous pathways are implicated …

Key points Muscle atrophy is a debilitating condition that affects a high percentage of the
population with a negative impact on quality of life. Dissecting the molecular level of the …

Aging reduces skeletal muscle mass and strength, but the underlying molecular
mechanisms remain elusive. Here, we used mouse models to investigate molecular …

Background Skeletal muscle mass and strength diminish during periods of disuse but
recover upon return to weight bearing in healthy adults but are incomplete in old muscle …

Klinefelter syndrome (KS) is the most common sex chromosomal disorder in males. Key
findings in older adolescents and young men are small testes with variable hypo …

Background Skeletal muscle dysfunction occurring as a result of ICU admission associates
with higher mortality. Although preadmission higher BMI correlates with better outcomes, the …