Statins are the most prescribed and effective drugs to treat cardiovascular diseases (CVD).
Nevertheless, these drugs can be responsible for skeletal muscle toxicity which leads to …

Frailty is associated with loss of functional reserve as well as with the prediction of adverse
events in the old population. The traditional criteria of frailty are based on five physical …

Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a
gradual loss of skeletal muscle, leading to the decline of muscle strength and physical …

Background Nitric oxide (NO), generated in skeletal muscle mostly by the neuronal NO
synthases (nNOSμ), has profound effects on both mitochondrial bioenergetics and muscle …

Satellite cells (SCs) are stem cells responsible for post-hatch muscle growth through
hypertrophy and in birds are sensitive to thermal stress during the first week after hatch. The …

The aging process induces significant changes in skeletal muscle morphology and
functionality. If not counteracted, this process, termed sarcopenia, can lead to progressively …

Molecular mechanisms that are associated with age-related denervation and loss of skeletal
muscle mass and function (sarcopenia) are described for female C57Bl/6J mice aged 3, 15 …

Sarcopenic obesity is a distinct condition of sarcopenia in the context of obesity, with the
cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) …

Resources are needed for growth, reproduction and survival, and organisms must trade off
limited resources among competing processes. Nutritional availability in organisms is …

Recent advances in our understanding of the biology of muscle have led to new interest in
the pharmacological treatment of muscle wasting. Loss of muscle mass and increased …