Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders

J Li, B Jia, Y Cheng, Y Song, Q Li… - Oxidative Medicine and …, 2022 - Wiley Online Library
With the acceleration of population aging, nervous system diseases including Alzheimer's
disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression …

Citrus flavonoids and their antioxidant evaluation

Y Wang, XJ Liu, JB Chen, JP Cao, X Li… - Critical Reviews in …, 2022 - Taylor & Francis
The antioxidant ability is the link and bridge connecting a variety of biological activities.
Citrus flavonoids play an essential role in regulating oxidative stress and are an important …

Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation

L Li, WJ Li, XR Zheng, QL Liu, Q Du, YJ Lai, SQ Liu - Molecular Medicine, 2022 - Springer
Background Alzheimer's disease (AD) is the most common type of neurodegenerative
disease in the contemporary era, and it is still clinically incurable. Eriodictyol, a natural …

The pharmacological and biological roles of eriodictyol

A Islam, MS Islam, MK Rahman, MN Uddin… - Archives of pharmacal …, 2020 - Springer
Eriodictyol is a flavonoid in the flavanones subclass. It is abundantly present in a wide range
of medicinal plants, citrus fruits, and vegetables that are considered to have potential health …

[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: a review

D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

The Nrf2/HO‐1 Axis as targets for flavanones: Neuroprotection by pinocembrin, naringenin, and Eriodictyol

S Habtemariam - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Flavanones are a group of flavonoids that derive from their immediate chalcone precursors
through the action of chalcone isomerase enzymes. The Aromatic A and B rings, C4‐keto …

COVID-19 and Long COVID: disruption of the neurovascular unit, blood-brain barrier, and tight junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

Bacterial biosynthesis of flavonoids: Overview, current biotechnology applications, challenges, and prospects

CO Okoye, H Jiang, Y Wu, X Li, L Gao… - Journal of Cellular …, 2023 - Wiley Online Library
Flavonoids are secondary metabolites present in plant organs and tissues. These natural
metabolites are the most prevalent and display a wide range of beneficial physiological …

Pharmacological activity of eriodictyol: the major natural polyphenolic flavanone

Z Deng, S Hassan, M Rafiq, H Li, Y He… - Evidence‐Based …, 2020 - Wiley Online Library
Eriodictyol is a flavonoid that belongs to a subclass of flavanones and is widespread in citrus
fruits, vegetables, and medicinally important plants. Eriodictyol has been anticipated to …

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway

W Li, Q Du, X Li, X Zheng, F Lv, X Xi, G Huang… - Frontiers in …, 2020 - frontiersin.org
Glioma is the most common type of malignant brain tumor. Due to its highly aggressive and
metastatic features, glioma is associated with poor prognosis and a lack of effective …