Homozygotes for loss-of-function mutations in ABCA1 cause Tangier disease. The
phenotype of their markedly reduced or loss of blood high-density lipoprotein (HDL) …

Atherosclerosis is a major pathogenic driver of cardiovascular diseases. Foam cell formation
plays a key role in atherogenesis, which is affected by lipid disorder and inflammation …

Abstract Purpose of Review Non-coding RNAs (ncRNAs) including microRNAs (miRNAs)
and circular RNAs (circRNAs) are pivotal regulators of mRNA and protein expression that …

MicroRNAs are small noncoding RNAs that regulate gene expression at the
posttranscriptional level. Since many microRNAs have multiple mRNA targets, they are …

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor
microenvironment (TME) and are critical for cancer initiation and progression. MicroRNAs …

The intestinal epithelium is a complex structure that integrates digestive, immunological,
neuroendocrine, and regenerative functions. Epithelial homeostasis is maintained by a …

Tissue mechanical properties are determined mainly by the extracellular matrix (ECM) and
actively maintained by resident cells. Despite its broad importance to biology and medicine …

Background Atherosclerosis is driven by synergistic interactions between pathological
biomechanical and lipid metabolic factors. Long noncoding RNAs (LncRNAs) have been …

Atherosclerosis (AS) is a chronic inflammatory disease seriously endangering human
health, whose occurrence and development is related to many factors. Pyroptosis is a …

Abstract miRNAs have emerged as critical regulators of nearly all biologic processes and
important therapeutic targets for numerous diseases. However, despite the tremendous …