[HTML][HTML] Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal Transduction and …, 2023 - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

[HTML][HTML] The microenvironment of the pathogenesis of cardiac hypertrophy

F Bazgir, J Nau, S Nakhaei-Rad, E Amin, MJ Wolf… - Cells, 2023 - mdpi.com
Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

A Versatile Passivated Protein‐Adsorption Platform for Rapid Healing of Vascular Stents by Modulating the Microenvironment

L Li, Z Cao, C Zhang, L Li, Q Li, C Liu… - Advanced Functional …, 2024 - Wiley Online Library
Biodegradable stents have paved the way to treat coronary artery disease. However, rapid
reendothelialization is required to solve the problems of mismatched degradation rates …

[HTML][HTML] Enhancement of PD-L1-attenuated CAR-T cell function through breast cancer-associated fibroblasts-derived IL-6 signaling via STAT3/AKT pathways

N Chuangchot, P Jamjuntra, S Yangngam… - Breast Cancer …, 2023 - Springer
Abstract Background Carcinoma-associated fibroblasts (CAFs) play a critical role in cancer
progression and immune cell modulation. In this study, it was aimed to evaluate the roles of …

Strategies for targeting cytokines in inflammatory bowel disease

MF Neurath - Nature Reviews Immunology, 2024 - nature.com
Cytokines produced by immune cells contribute to the development and perpetuation of
inflammatory bowel disease (IBD), namely Crohn's disease and ulcerative colitis, by …

The protease ADAM17 at the crossroads of disease: Revisiting its significance in inflammation, cancer, and beyond

MI Saad, BJ Jenkins - The FEBS Journal, 2024 - Wiley Online Library
The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the
pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of …

[HTML][HTML] Anti-inflammatory effects of serotonin receptor and transient receptor potential channel ligands in human small intestinal epithelial cells

GI Robinson, D Li, B Wang, Y Zahoruiko… - Current Issues in …, 2023 - mdpi.com
Intestinal inflammation and dysbiosis can lead to inflammatory bowel diseases (IBD) and
systemic inflammation, affecting multiple organs. Developing novel anti-inflammatory …

The ouroboros of autoimmunity

JL Casanova, J Peel, J Donadieu, AL Neehus… - Nature …, 2024 - nature.com
Human autoimmunity against elements conferring protective immunity can be symbolized by
the 'ouroboros', a snake eating its own tail. Underlying infection is autoimmunity against …

[HTML][HTML] Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors

TYS Ngaha, AV Zhilenkova, FE Essogmo, IK Uchendu… - Cancers, 2023 - mdpi.com
Simple Summary Growth factors promote angiogenesis, which is a critical process in the
development of tumors. One of the therapeutic techniques being investigated in the …

[HTML][HTML] Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

SSK Hansen, R Krautz, D Rago, J Havelund… - Nature …, 2024 - nature.com
The fetal development of organs and functions is vulnerable to perturbation by maternal
inflammation which may increase susceptibility to disorders after birth. Because it is not well …