Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …

[HTML][HTML] Natural history of COVID-19 and current knowledge on treatment therapeutic options

WG Dos Santos - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Despite intense research there is currently no effective vaccine available against the new
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 …

[HTML][HTML] Activation and evasion of type I interferon responses by SARS-CoV-2

X Lei, X Dong, R Ma, W Wang, X Xiao, Z Tian… - Nature …, 2020 - nature.com
The pandemic of COVID-19 has posed an unprecedented threat to global public health.
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …

COVID-19 cytokine storm: the interplay between inflammation and coagulation

RJ Jose, A Manuel - The Lancet Respiratory Medicine, 2020 - thelancet.com
Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the globe. It is
associated with significant mortality, particularly in at-risk groups with poor prognostic …

[PDF][PDF] Heightened innate immune responses in the respiratory tract of COVID-19 patients

Z Zhou, L Ren, L Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - Cell host & …, 2020 - cell.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

Y Yang, C Shen, J Li, J Yuan, J Wei, F Huang… - Journal of Allergy and …, 2020 - Elsevier
Background The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 was first reported in Wuhan, December 2019, and …

[HTML][HTML] The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria

DB Kell, EL Heyden, E Pretorius - Frontiers in immunology, 2020 - frontiersin.org
Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …

[HTML][HTML] The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

[HTML][HTML] Comparison of nonhuman primates identified the suitable model for COVID-19

S Lu, Y Zhao, W Yu, Y Yang, J Gao, J Wang… - Signal transduction and …, 2020 - nature.com
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains
challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 …