Blood-sucking arthropods transmit a variety of human pathogens acting as disseminators of
the so-called vector-borne diseases. Leishmaniasis is a spectrum of diseases caused by …

Leishmaniases are vector-borne parasitic diseases with 0.9–1.4 million new human cases
each year worldwide. In the vectorial part of the life-cycle, Leishmania development is …

The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …

Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …

A thorough understanding of the transmission mechanism of any infectious agent is crucial
to implementing an effective intervention strategy. Here, our current understanding of the …

Despite several studies describing the secretion of exosomes by Leishmania in vitro,
observation of their formation and release in vivo has remained a major challenge. Herein …

About 1.5 million new cases of cutaneous leishmaniasis and 500 000 new cases of visceral
leishmaniasis occur each year around the world. For over half a century, the clinical forms of …

Galectins, which were first characterized in the mid-1970s, were assigned a role in the
recognition of endogenous ('self') carbohydrate ligands in embryogenesis, development and …

The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Each meal is
a potential infection because some bacteria have evolved mechanisms to resist predation …

Since the early 1980s, visceral leishmaniasis (VL) which is, in general, a rural zoonotic
disease, has spread to the urban centers of the north, and now the south and west of Brazil …