Copper in Gynecological Diseases

RA Conforti, MB Delsouc, E Zorychta… - International Journal of …, 2023 - mdpi.com
Copper (Cu) is an essential micronutrient for the correct development of eukaryotic
organisms. This metal plays a key role in many cellular and physiological activities …

The importance of being Casiopeina as polypharmacologycal profile (mixed chelate–copper (II) complexes and their in vitro and in vivo activities)

Z Aguilar-Jiménez, A Espinoza-Guillén… - Inorganics, 2023 - mdpi.com
In this review, we present a timeline that shows the origin of mixed chelate copper (II)
complexes, registered as Mark Title Casiopeínas®, as the first copper (II) compounds …

Current trends on the involvement of zinc, copper, and selenium in the process of hepatocarcinogenesis

T Himoto, T Masaki - Nutrients, 2024 - mdpi.com
Numerous nutritional factors increase the risk of hepatocellular carcinoma (HCC)
development. The dysregulation of zinc, copper, and selenium homeostasis is associated …

Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials

J Wang, J Li, J Liu, KY Chan, HS Lee, KN Lin… - Cancers, 2024 - mdpi.com
Simple Summary In the complex world of cancer, iron and copper play essential roles as
trace metal ions that are crucial for cancer cell survival. Disruption in their metabolic …

Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy

C Springer, D Humayun, R Skouta - Cancers, 2024 - mdpi.com
Simple Summary Cuproptosis is a recently identified form of cell death induced by
imbalanced copper levels. We aimed to explore the mechanism underlying copper-induced …

Unveiling the promising anticancer effect of copper-based compounds: A comprehensive review

S Abdolmaleki, A Aliabadi, S Khaksar - Journal of Cancer Research and …, 2024 - Springer
Copper is a necessary micronutrient for maintaining the well-being of the human body. The
biological activity of organic ligands, especially their anticancer activity, is often enhanced …

Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy–Significance for cancer treatment?

M Kciuk, A Gielecińska, Ż Kałuzińska-Kołat… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Apoptosis has traditionally been regarded as the desired cell death pathway activated by
chemotherapeutic drugs due to its controlled and non-inflammatory nature. However, recent …

[HTML][HTML] COX19 is a new target of MACC1 and promotes colorectal cancer progression by regulating copper transport in mitochondria

S Gao, H Zhang, X Zhang, J Wang, W Bai… - The Journal of Nutrition, 2024 - Elsevier
Background Recent studies have demonstrated that copper (Cu) plays an important role in
the progression of tumor diseases. Metastasis associated with colon cancer protein 1 …

A Cuproptosis-related Gene DLAT as a Novel Prognostic Marker and its Relevance to Immune Infiltration in Low-grade Gliomas

P Gao, H Li, Y Qiao, J Nie, S Cheng, G Tang, X Dai… - Heliyon, 2024 - cell.com
DLAT has been recognized as a cuproptosis-related gene that is crucial for cuproptosis in
earlier research. The study is to look at how DLAT affects individuals with low-grade glioma's …

Pan‐Cancer Analysis of the Cuproptosis‐Related Gene DLD

J Lin, G Wang, S Cheng, Y Hu, H Li… - Mediators of …, 2023 - Wiley Online Library
Background. Cancer affects millions of people each year and imposes a huge economic and
social burden worldwide. Cuproptosis is a recently discovered novel mode of cell death. The …