How to overcome constraints imposed by microsporidian genome features to ensure gene prediction?

E Peyretaillade, RF Akossi, J Tournayre… - Journal of Eukaryotic …, 2024 - Wiley Online Library
Since the advent of sequencing techniques and due to their continuous evolution, it has
become easier and less expensive to obtain the complete genome sequence of any …

Position-dependent function of human sequence-specific transcription factors

SH Duttke, C Guzman, M Chang, NP Delos Santos… - Nature, 2024 - nature.com
Patterns of transcriptional activity are encoded in our genome through regulatory elements
such as promoters or enhancers that, paradoxically, contain similar assortments of …

Sourcing DNA parts for synthetic biology applications in plants

K Vollen, C Zhao, JM Alonso, AN Stepanova - Current Opinion in …, 2024 - Elsevier
Highlights•Synthetic biology applications rely on collections of sequence-verified DNA
parts.•The choice of DNA parts in a construct determines its utility and effectiveness.• …

LINE1-mediated epigenetic repression of androgen receptor transcription causes androgen insensitivity syndrome

J Pozojevic, R Sivaprasad, J Laß, F Haarich, J Trinh… - Scientific Reports, 2024 - nature.com
Androgen insensitivity syndrome (AIS) is a difference of sex development (DSD)
characterized by different degrees of undervirilization in individuals with a 46, XY karyotype …

Genome assembly of Medicago truncatula accession SA27063 provides insight into spring black stem and leaf spot disease resistance

JR Botkin, AD Farmer, ND Young, SJ Curtin - BMC genomics, 2024 - Springer
Medicago truncatula, model legume and alfalfa relative, has served as an essential resource
for advancing our understanding of legume physiology, functional genetics, and crop …

Combining a prioritization strategy and functional studies nominates 5'UTR variants underlying inherited retinal disease

A Dueñas Rey, M del Pozo Valero, M Bouckaert… - Genome Medicine, 2024 - Springer
Abstract Background 5'untranslated regions (5'UTRs) are essential modulators of protein
translation. Predicting the impact of 5'UTR variants is challenging and rarely performed in …

Integration of Epigenome and Lactylome Reveals the Regulation of Lipid Production in Nannochloropsis oceanica

L Ouyang, J Wang, H Zhu, Y Wu… - Journal of Agricultural and …, 2024 - ACS Publications
Lysine lactylation (Kla) is a kind of novel post-translational modification (PTM) that
participates in gene expression and various metabolic processes. Nannochloropsis has a …

Translational control of papillomavirus mRNAs in the spotlight

A García, G Maldonado, G Hernández - Trends in Cell Biology, 2024 - cell.com
High-risk human papillomaviruses (HPVs) cause most cases of cervical cancer, a disease
with an increasing impact worldwide. Recent studies have shown that the synthesis of viral …

Characterization and optimization of 5´ untranslated region containing poly-adenine tracts in Kluyveromyces marxianus using machine-learning model

J Zeng, K Song, J Wang, H Wen, J Zhou, T Ni… - Microbial Cell …, 2024 - Springer
Background The 5´ untranslated region (5´ UTR) plays a key role in regulating translation
efficiency and mRNA stability, making it a favored target in genetic engineering and …

[HTML][HTML] TNFAIP2 as an emerging therapeutic target in cancer therapy and its underlying mechanisms

Z Fu, Y Yuan - Pharmacological Research, 2024 - Elsevier
TNFα-induced protein 2 (TNFAIP2), upregulated under TNFα stimulation, was initially
thought to participate in angiogenesis. Still, more and more studies have found that TNFAIP2 …