Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD)
molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new …

Molecular glues are a class of small molecules that stabilize the interactions between
proteins. Naturally occurring molecular glues are present in many areas of biology where …

The integration of artificial intelligence (AI) into point-of-care (POC) biosensing has the
potential to revolutionize diagnostic methodologies by offering rapid, accurate, and …

PROteolysis TArgeting Chimeras (PROTACs) are hetero-bifunctional small molecules that
can simultaneously recruit target proteins and E3 ligases to form a ternary complex …

Artificial intelligence (AI) is a powerful approach for solving complex problems in the
processing, analysis, and interpretation of omics data, as well as the integration of multi …

Targeted protein degradation has recently gained widespread interest as both a novel
therapeutic strategy and a useful tool in biomedical research. Targeted protein degraders …

PROTACs have emerged as a new class of drugs that can target the “undruggable”
proteome by hijacking the ubiquitin proteasome system. Despite PROTACs' success, most …

PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology
and drug discovery. This technique facilitates the complete removal of the target proteins …

Fusion oncoproteins are associated with childhood cancers and have proven challenging to
target, aside from those that include kinases. As part of its efforts for targeting childhood …

Bivalent proximity-inducing compounds represent a novel class of small molecule
therapeutics with exciting potential and new challenges. The most prominent examples of …