Systems genetics for mechanistic discovery in heart diseases
Cardiovascular diseases are the leading cause of death worldwide. Complex diseases with
highly heterogenous disease progression among patient populations, cardiovascular …
highly heterogenous disease progression among patient populations, cardiovascular …
[HTML][HTML] A comprehensive evaluation of computational tools to identify differential methylation regions using RRBS data
DNA methylation plays a vital role in transcription regulation. Reduced representation
bisulfite sequencing (RRBS) is becoming common for analyzing genome-wide methylation …
bisulfite sequencing (RRBS) is becoming common for analyzing genome-wide methylation …
[HTML][HTML] IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis
Identifying genetic variants that are associated with methylation variation—an analysis
commonly referred to as methylation quantitative trait locus (mQTL) mapping—is important …
commonly referred to as methylation quantitative trait locus (mQTL) mapping—is important …
[HTML][HTML] Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice
VP Tryndyak, T Han, JC Fuscoe, SA Ross, FA Beland… - BMC genomics, 2016 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a
leading cause of chronic liver disease in the United States and Western countries. In …
leading cause of chronic liver disease in the United States and Western countries. In …
[HTML][HTML] DNA Methylation Patterns According to Fatty Liver Index and Longitudinal Changes from the Korean Genome and Epidemiology Study (KoGES)
YK Ko, H Kim, Y Lee, YS Lee, JA Gim - Current Issues in Molecular …, 2022 - mdpi.com
The role of differentially methylated regions (DMRs) in nonalcoholic fatty liver disease
(NAFLD) is unclear. This study aimed to identify the role of DMR in NAFLD development and …
(NAFLD) is unclear. This study aimed to identify the role of DMR in NAFLD development and …
[HTML][HTML] Chromatin variation associated with liver metabolism is mediated by transposable elements
Background Functional regulatory regions in eukaryotic genomes are characterized by the
disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin …
disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin …
The genetics of variation of the wave 1 amplitude of the mouse auditory brainstem response
This is the first genome-wide association study with the Hybrid Mouse Diversity Panel
(HDMP) to define the genetic landscape of the variation in the suprathreshold wave 1 …
(HDMP) to define the genetic landscape of the variation in the suprathreshold wave 1 …
[HTML][HTML] Mammalian non-CG methylations are conserved and cell-type specific and may have been involved in the evolution of transposon elements
Although non-CG methylations are abundant in several mammalian cell types, their
biological significance is sparsely characterized. We gathered 51 human and mouse DNA …
biological significance is sparsely characterized. We gathered 51 human and mouse DNA …
Non-coding genome functions in diabetes
I Cebola, L Pasquali - Journal of molecular endocrinology, 2016 - jme.bioscientifica.com
Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …
studies, does not reside in protein-coding regions, making the identification of functional …
Invited review: Measurable biomarkers linked to meat quality from different pig production systems
MFW Te Pas, B Lebret, N Oksbjerg - Archives Animal Breeding, 2017 - aab.copernicus.org
Biological processes underlie all livestock traits, including post-mortem meat quality traits.
Biomarkers are molecular components of the biological processes showing differential …
Biomarkers are molecular components of the biological processes showing differential …