DNA methylation is an important gene regulatory mechanism that contributes to the
genotype-phenotype relationship. Identifying genetic variants that are associated with …

When the response on a subject can be naturally viewed as a smooth curve or function, it is
said to be a functional response. The response may be observed at a set of discrete times …

Epigenetic mechanisms underlying phenotypic change are hypothesized to contribute to 26
population persistence and adaptation in the face of environmental change. To date, few …

Genes are the functional units of heredity. However, the functions of many genes remain
unknown, which impedes the understanding of the underlying mechanism of complex traits …

The chromatin architectural rearrangements that permit disease gene expression are just
beginning to come to light. Distinct levels of chromatin organization are needed to maintain …

Our capabilities to define cardiovascular health and disease using highly multivariate
“omics” datasets have substantially increased in recent years. Advances in acquisition …

As the volume of transcriptomic data continues to increase, so too does its potential to
deepen our understanding of disease; for example, by revealing gene expression patterns …

The past few decades have seen dramatic increase in the prevalence of metabolic diseases
(MetDs) including obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) …

Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …

Post-operative atrial fibrillation (POAF) is a common cause of morbidity and mortality after
cardiac surgery. Although clinical risk factors exist, their accuracy is insufficient for …