Nanoparticles in clinical trials: analysis of clinical trials, FDA approvals and use for COVID-19 vaccines
ED Namiot, AV Sokolov, VN Chubarev… - International journal of …, 2023 - mdpi.com
Nanoparticles are heterologous small composites that are usually between 1 and 100
nanometers in size. They are applied in many areas of medicine with one of them being …
nanometers in size. They are applied in many areas of medicine with one of them being …
Rise of the RNA machines–self-amplification in mRNA vaccine design
JDG Comes, GP Pijlman, TAH Hick - Trends in Biotechnology, 2023 - cell.com
Abstract mRNA vaccines have won the race for early COVID-19 vaccine approval, yet
improvements are necessary to retain this leading role in combating infectious diseases. A …
improvements are necessary to retain this leading role in combating infectious diseases. A …
A localizing nanocarrier formulation enables multi-target immune responses to multivalent replicating RNA with limited systemic inflammation
T Kimura, JM Leal, A Simpson, NL Warner, BJ Berube… - Molecular Therapy, 2023 - cell.com
RNA vaccines possess significant clinical promise in counteracting human diseases caused
by infectious or cancerous threats. Self-amplifying replicon RNA (repRNA) has been thought …
by infectious or cancerous threats. Self-amplifying replicon RNA (repRNA) has been thought …
Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination
LE Adams, SR Leist, KH Dinnon, A West, KL Gully… - Cell Reports, 2023 - cell.com
Group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in
modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective …
modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective …
Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge
SS Leventhal, K Meade-White, D Rao, E Haddock… - …, 2022 - thelancet.com
Summary Background Crimean-Congo hemorrhagic fever virus is the cause of a severe
hemorrhagic fever with cases reported throughout a wide-geographic region. Spread by the …
hemorrhagic fever with cases reported throughout a wide-geographic region. Spread by the …
Pre-existing immunity modulates responses to mRNA boosters
Summary mRNA vaccines are effective in preventing severe COVID-19, but breakthrough
infections, emerging variants, and waning immunity warrant the use of boosters. Although …
infections, emerging variants, and waning immunity warrant the use of boosters. Although …
Design strategies for and stability of mRNA–lipid nanoparticle COVID-19 vaccines
T Liu, Y Tian, A Zheng, C Cui - Polymers, 2022 - mdpi.com
Messenger RNA (mRNA) vaccines have shown great preventive potential in response to the
novel coronavirus (COVID-19) pandemic. The lipid nanoparticle (LNP), as a non-viral vector …
novel coronavirus (COVID-19) pandemic. The lipid nanoparticle (LNP), as a non-viral vector …
The rise and fall of SARS-CoV-2 variants and ongoing diversification of omicron
In late December of 2019, high-throughput sequencing technologies enabled rapid
identification of SARS-CoV-2 as the etiological agent of COVID-19, and global sequencing …
identification of SARS-CoV-2 as the etiological agent of COVID-19, and global sequencing …
[HTML][HTML] Tuberculosis vaccines update: Is an RNA-based vaccine feasible for tuberculosis?
SE Larsen, SL Baldwin, RN Coler - International Journal of Infectious …, 2023 - Elsevier
Abstract Objectives Despite concerted efforts, Mycobacterium tuberculosis (M. tb), the
pathogen that causes tuberculosis (TB), continues to be a burden on global health …
pathogen that causes tuberculosis (TB), continues to be a burden on global health …
A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned
MA O'Connor, DW Hawman, K Meade-White… - Plos …, 2023 - journals.plos.org
The global SARS-CoV-2 pandemic prompted rapid development of COVID-19 vaccines.
Although several vaccines have received emergency approval through various public health …
Although several vaccines have received emergency approval through various public health …