A guide to current methodology and usage of reverse vaccinology towards in silico vaccine discovery
SJ Goodswen, PJ Kennedy… - FEMS Microbiology …, 2023 - academic.oup.com
Reverse vaccinology (RV) was described at its inception in 2000 as an in silico process that
starts from the genomic sequence of the pathogen and ends with a list of potential protein …
starts from the genomic sequence of the pathogen and ends with a list of potential protein …
Immune-checkpoint inhibitors from cancer to COVID-19: A promising avenue for the treatment of patients with COVID-19
S Vivarelli, L Falzone, F Torino… - International …, 2020 - spandidos-publications.com
The severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV-2) poses a
threat to human life worldwide. Since early March, 2020, coronavirus disease 2019 (COVID …
threat to human life worldwide. Since early March, 2020, coronavirus disease 2019 (COVID …
The COVID-19 vaccine development: a pandemic paradigm
DC Carneiro, JD Sousa, JP Monteiro-Cunha - Virus Research, 2021 - Elsevier
COVID-19 pandemic has resulted in millions of deaths and a social-economic crisis. A
worldwide effort was made to develop efficient vaccines for this disease. A vaccine should …
worldwide effort was made to develop efficient vaccines for this disease. A vaccine should …
Forecasting the impact of environmental stresses on the frequent waves of COVID19
A novel approach to link the environmental stresses with the COVID-19 cases is adopted
during this research. The time-dependent data are extracted from the online repositories that …
during this research. The time-dependent data are extracted from the online repositories that …
In silico clinical trials for relapsing-remitting multiple sclerosis with MS TreatSim
Background The last few decades have seen the approval of many new treatment options
for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic …
for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic …
A systematic review of cardiac in-silico clinical trials
C Rodero, TMG Baptiste, RK Barrows… - Progress in …, 2023 - iopscience.iop.org
Computational models of the heart are now being used to assess the effectiveness and
feasibility of interventions through in-silico clinical trials (ISCTs). As the adoption and …
feasibility of interventions through in-silico clinical trials (ISCTs). As the adoption and …
[HTML][HTML] A contemporary review on the important role of in silico approaches for managing different aspects of COVID-19 crisis
In the last century, the emergence of in silico tools has improved the quality of healthcare
studies by providing high quality predictions. In the case of COVID-19, these tools have …
studies by providing high quality predictions. In the case of COVID-19, these tools have …
A multi-step and multi-scale bioinformatic protocol to investigate potential SARS-CoV-2 vaccine targets
The COVID-19 pandemic has highlighted the need to come out with quick interventional
solutions that can now be obtained through the application of different bioinformatics …
solutions that can now be obtained through the application of different bioinformatics …
In silico studies to support vaccine development
The progress that has been made in computer science positioned in silico studies as an
important and well-recognized methodology in the drug discovery and development …
important and well-recognized methodology in the drug discovery and development …
The promises of speeding up: Changes in requirements for animal studies and alternatives during COVID-19 vaccine approval–A case study
M Ritskes-Hoitinga, Y Barella, T Kleinhout-Vliek - Animals, 2022 - mdpi.com
Simple Summary The COVID-19 pandemic led to intensive research into finding new
vaccines for human protection. On 21 December 2020, the European Commission granted …
vaccines for human protection. On 21 December 2020, the European Commission granted …