High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Immune outcomes are key mediators of many health benefits of exercise and are
determined by exercise type, dose (frequency/duration, intensity), and individual …

Background Ascending to high altitude can induce a range of physiological and molecular
alterations, rendering a proportion of lowlanders unacclimatized. The prediction of acute …

The harsh environment in the Tibetan plateau, the highest place in the world, poses
thermoregulatory challenges and hypoxic stress to animals. The impacts of plateau …

Bumblebees are among the most abundant and important pollinators for sub-alpine and
alpine flowering plant species in the Northern Hemisphere, but little is known about their …

Exercise in hypoxia increases immune responses compared with normoxic exercise, and
while Toll-like receptor 4 (TLR4) is implicated in these responses, its regulation remains …

Acute high-altitude (HA) exposure can induce several pathologies. Dexamethasone (DEX)
can be taken prophylactically to prevent HA disease, but the mechanism by which it acts in …

High‐altitude cardiac injury (HACI) is one of the common tissue injuries caused by high‐
altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG‐R1), a major saponin …

Background and objectives Acute mountain sickness (AMS) is a pathology with different
symptoms in which the organism is not adapted to the environment that occurs under the …

Pentoxifylline is a nonselective phosphodiesterase inhibitor used for the treatment of
peripheral artery disease. Pentoxifylline acts through cyclic adenosine monophosphate …