Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …

The evolutionary origin of eukaryotes spurred the transition from prokaryotic‐like translation
to a more sophisticated, eukaryotic translation. During this process, successive gene …

The molecular mechanisms connecting cellular metabolism with differentiation remain
poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation …

Abstract All 37 mitochondrial DNA (mtDNA)-encoded genes involved with oxidative
phosphorylation and intramitochondrial protein synthesis, and several nuclear-encoded …

Gene expression is controlled by the precise activation and repression of transcription.
Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors …

Insect odorant receptors and gustatory receptors define a superfamily of seven
transmembrane domain ion channels (referred to here as 7TMICs), with homologs identified …

Codon usage bias has long been appreciated to influence protein production. Yet, relatively
few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein …

Background The nose of most animals comprises multiple sensory subsystems, which are
defined by the expression of different olfactory receptor families. Drosophila melanogaster …

In mammals, energy homeostasis is regulated by the antagonistic action of hormones insulin
and glucagon. However, in contrast to the highly conserved insulin, glucagon is absent in …