Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways

R Vaka, S Parent, Y Risha, S Khan, D Courtman… - … Therapy-Nucleic Acids, 2023 - cell.com
The cell origin-specific payloads within extracellular vesicles (EVs) mediate therapeutic
bioactivity for a wide variety of stem cell types. In this study, we profiled the microRNA …

[HTML][HTML] Nanotechnology and COVID-19: Prevention, diagnosis, vaccine, and treatment strategies

S Ayan, K Aranci-Ciftci, F Ciftci, CB Ustundag - Frontiers in Materials, 2023 - frontiersin.org
In December 2019, Coronavirus pandemic (COVID-19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) viruses, which affected the whole world, is …

Prophylactic administration of mesenchymal stromal cells does not prevent arrested lung development in extremely premature-born non-human primates

MA Möbius, SR Seidner, DC McCurnin… - Stem Cells …, 2023 - academic.oup.com
Premature birth is a leading cause of childhood morbidity and mortality and often followed
by an arrest of postnatal lung development called bronchopulmonary dysplasia. Therapies …

[HTML][HTML] Characteristics and possible mechanisms of metabolic disorder in overweight women with polycystic ovary syndrome

J Yu, Y Zhou, J Ding, D Zhang, C Yu… - Frontiers in …, 2023 - frontiersin.org
Background Polycystic ovary syndrome (PCOS) is a kind of endocrine and metabolic
disorder, disturbing the females of reproductive age. Here, we aimed to investigate the …

[HTML][HTML] Inactivation of the NLRP3 inflammasome mediates exosome-based prevention of atrial fibrillation

S Parent, R Vaka, J St Amant, S Kahn… - Theranostics, 2024 - ncbi.nlm.nih.gov
Abstract Rationale: Extracellular vesicles (EVs) from human explant-derived cells injected
directly into the atria wall muscle at the time of open chest surgery reduce atrial fibrosis …

Characterizing Macrophages Diversity in COVID-19 Patients Using Deep Learning

MA Flores, K Paniagua, W Huang, R Ramirez, L Falcon… - Genes, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent
responsible for coronavirus disease 2019 (COVID-19), has affected the lives of billions and …

[HTML][HTML] Exploring Patient Viewpoints to Optimize Implementation of a Biological Therapy for Atrial Fibrillation Prevention

C Smith, MM Lalu, DR Davis - CJC Open, 2024 - Elsevier
Background Embracing patient viewpoints can enhance the translation of novel therapeutics
to clinical settings. This study evaluated the acceptability of using extracellular vesicles …

[HTML][HTML] Tea ingredients have anti-coronavirus disease 2019 (COVID-19) targets based on bioinformatics analyses and pharmacological effects on LPS-stimulated …

L Wang, Q Tao, Z Wang, J Shi, W Yan, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused millions of deaths and lacks …

Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment

Y Huang, X Li, L Yang - Stem Cell Research & Therapy, 2022 - Springer
Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens
to the whole world, seriously affecting global economic growth, and threatening people's …

[PDF][PDF] Characterizing Macrophages Diversity in COVID-19 Patients Using Deep Learning. Genes 2022, 13, 2264

MA Flores, K Paniagua, W Huang, R Ramirez, L Falcon… - 2022 - academia.edu
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent
responsible for coronavirus disease 2019 (COVID-19), has affected the lives of billions and …