Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults with poor
prognosis. Despite the current state of knowledge on its genetic characteristics, relatively …

Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1
(SCCA1, now referred to as SERPINB3) commonly experience treatment resistance and …

Hemophagocytic lymphohistiocytosis (HLH) is a highly fatal condition with the positive
feedback loop between continued immune cell activation and cytokine storm as the core …

The periosteum plays a critical role in bone development, shaping, remodeling, and fracture
healing due to its abundance of osteoprogenitor cells, osteoblasts, and capillary network …

There is evidence to suggest that the primary tumor induces the formation of a pre-metastatic
niche in distal organs by stimulating the production of pro-metastatic factors. Given the …

The DNA-sensing cGAS-STING pathway promotes the senescence-associated secretory
phenotype (SASP) and mediates type-I interferon inflammatory responses to foreign viral …

Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist
of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further …

Stereotactic radiotherapy (SRT) has become an attractive treatment modality in full bloom in
recent years by presenting itself as a safe, noninvasive alternative to surgery to control …

Objective The primary purpose of this study was to investigate the contribution of genetic
predispositions to depression and inflammation, as measured through polygenic risk scores …