Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own T lymphocytes are
engineered to recognize and kill cancer cells, has achieved striking success in some …

Background and Aims Mucosal‐associated invariant T (MAIT) cells are nonconventional T
cells restricted to major histocompatibility complex class I–related protein 1 (MR1). They are …

Simple Summary Chimeric antigen receptors (CAR) are engineered molecules expressed
on the cell surface that can recognise specific proteins and deliver an activation signal to the …

Conclusion In this US study, 1.5% of patients with AHP had HCC. HCC in AHP occurred in
the absence of cirrhosis, which contrasts with other chronic liver diseases. Patients with …

Hepatocellular carcinoma (HCC) is characterized by poor outcome and shows limited drug-
response in clinical trials. Tumor immune microenvironment (TIME) exerts a strong selection …

Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented
by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors …

MAIT cells are one representative of a group of related unconventional or pre-set T cells,
and are particularly abundant in humans. While these unconventional T cell types, which …

More than 95% of adult infected with HBV show acute self-limited infection and eventually
eliminate the virus. In contrast, about 90% of people exposed to HBV in early childhood …

Immune checkpoint inhibitors (ICIs) are specialized monoclonal antibodies (mAbs) that
target immune checkpoints and their ligands, counteracting cancer cell-induced T-cell …

Novel treatments based upon the use of immune checkpoint inhibitors have an impressive
efficacy in different types of cancer. Unfortunately, most patients do not derive benefit or …