Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

CJ Kim, R Romero, P Chaemsaithong… - American journal of …, 2015 - Elsevier
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …

[PDF][PDF] Inflammatory pathways in female reproductive health and disease

HN Jabbour, KJ Sales, RD Catalano, JE Norman - Reproduction, 2009 - Citeseer
Inflammation involves alterations to vascular and immune cell function. It is well recognised
that many physiological reproductive events such as ovulation, menstruation, implantation …

Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

IA Stelzer, MS Ghaemi, X Han, K Ando… - Science translational …, 2021 - science.org
Estimating the time of delivery is of high clinical importance because pre-and postterm
deviations are associated with complications for the mother and her offspring. However …

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

R Romero, J Miranda, P Chaemsaithong… - The journal of …, 2015 - Taylor & Francis
Objective: The objectives of this study were to:(1) determine the amniotic fluid (AF)
microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) …

Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre‐labor rupture of …

DB DiGiulio, R Romero, JP Kusanovic… - American journal of …, 2010 - Wiley Online Library
Citation DiGiulio DB, Romero R, Kusanovic JP, Gómez R, Kim CJ, Seok K, Gotsch F, Mazaki‐
Tovi S, Vaisbuch E, Sanders K, Bik EM, Chaiworapongsa T, Oyarzún E, Relman DA …

[HTML][HTML] The frequency and type of placental histologic lesions in term pregnancies with normal outcome

R Romero, YM Kim, P Pacora, CJ Kim… - Journal of perinatal …, 2018 - degruyter.com
Objective To determine the frequency and type of histopathologic lesions in placentas
delivered by women with a normal pregnancy outcome. Methods This retrospective cohort …

Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1

R Romero, T Chaiworapongsa… - The journal of …, 2011 - Taylor & Francis
Objective. Preterm parturition is a syndrome caused by multiple etiologies. Although intra-
amniotic infection is causally linked with intrauterine inflammation and the onset of preterm …

The occurrence of preterm delivery is linked to pregnancy-specific distress and elevated inflammatory markers across gestation

ME Coussons-Read, M Lobel, JC Carey… - Brain, behavior, and …, 2012 - Elsevier
There is mounting evidence that stress during pregnancy can have detrimental effects on
gestation and birth. Existing studies indicate that prenatal stress may increase levels of …

A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes

P Chaemsaithong, R Romero… - The Journal of …, 2016 - Taylor & Francis
Objective: Preterm birth is associated with 5–18% of pregnancies and is the leading cause
of neonatal morbidity and mortality. Amniotic fluid (AF) interleukin-6 (IL-6) is a key cytokine …

Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth

JA Keelan - Journal of Reproductive Immunology, 2018 - Elsevier
The central role of inflammatory processes in labour and delivery is now well-recognised.
However, the biomolecular, immunological and endocrine mechanisms involved in the …