Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis
Sepsis, a potentially fatal illness caused by an improper host response to infection, remains
a serious problem in the world of healthcare. In recent years, the role of ncRNA has …
a serious problem in the world of healthcare. In recent years, the role of ncRNA has …
Metabolism-inflammasome crosstalk shapes innate and adaptive immunity
J Wu, X Sun, P Jiang - Cell Chemical Biology, 2024 - cell.com
Inflammasomes are a central component of innate immunity and play a vital role in
regulating innate immune response. Activation of inflammasomes is also indispensable for …
regulating innate immune response. Activation of inflammasomes is also indispensable for …
[HTML][HTML] GDF3 protects mice against sepsis-induced acute lung injury by suppression of macrophage pyroptosis
J Lei, L Wang, L Zou, H Wang, Y Zhang, S Liu, M Pan… - Pharmaceuticals, 2024 - mdpi.com
Sepsis-induced ALI is marked by physiological, pathological, and biochemical irregularities
caused by infection. Growth differentiation factor 3 (GDF3) is closely associated with the …
caused by infection. Growth differentiation factor 3 (GDF3) is closely associated with the …
[HTML][HTML] Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to …
W Zhu, N Lian, J Wang, F Zhao, B Liu, J Sheng… - Chinese Medicine, 2024 - Springer
Abstract Background Liguzinediol (Lig) has emerged as a promising candidate for mitigating
Doxorubicin (DOX)-induced cardiotoxicity, a significant limitation in the clinical application of …
Doxorubicin (DOX)-induced cardiotoxicity, a significant limitation in the clinical application of …
[HTML][HTML] Maresin1 alleviates neuroinflammation by inhibiting caspase-3/GSDME-mediated pyroptosis in mice cerebral ischemia-reperfusion model
M Zhao, W Xian, W Liu, D Chen, S Wang… - Journal of Stroke and …, 2024 - Elsevier
Objective To explore the mechanism of Maresin1 in reducing cerebral ischemia-reperfusion
injury. Materials and methods Male C57BL/6 mice were randomly divided (n= 5 in each …
injury. Materials and methods Male C57BL/6 mice were randomly divided (n= 5 in each …