Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A
unique aspect of human papillomavirus molecular biology involves dependence on the …

Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Summary Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in
ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role …

Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us
huge amounts of data on their expression, functions and structures. We know much about …

Human papillomavirus (HPV) is the most common sexually transmitted infectious agent
worldwide, being also responsible for 5% of all human cancers. The integration and …