The fight against cancer by microgravity: the multicellular spheroid as a metastasis model
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …
The translational challenges of precision oncology
The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …
biological complexity and diversity of this disease. Technological advances in genomics …
[HTML][HTML] Genome-wide mapping of somatic mutation rates uncovers drivers of cancer
Identification of cancer driver mutations that confer a proliferative advantage is central to
understanding cancer; however, searches have often been limited to protein-coding …
understanding cancer; however, searches have often been limited to protein-coding …
Genome-wide analysis of somatic noncoding mutation patterns in cancer
F Dietlein, AB Wang, C Fagre, A Tang, NJM Besselink… - Science, 2022 - science.org
We established a genome-wide compendium of somatic mutation events in 3949 whole
cancer genomes representing 19 tumor types. Protein-coding events captured well …
cancer genomes representing 19 tumor types. Protein-coding events captured well …
Characterizing and explaining the impact of disease-associated mutations in proteins without known structures or structural homologs
Mutations in human proteins lead to diseases. The structure of these proteins can help
understand the mechanism of such diseases and develop therapeutics against them. With …
understand the mechanism of such diseases and develop therapeutics against them. With …
Biological and clinical perspectives of TERT promoter mutation detection on bladder cancer diagnosis and management
L Cheng, S Zhang, M Wang, A Lopez-Beltran - Human Pathology, 2022 - Elsevier
The telomerase reverse transcriptase (TERT) promoter mutations are associated with
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …
[HTML][HTML] Biomolecular condensates in cancer biology
HI Suzuki, K Onimaru - Cancer Science, 2022 - ncbi.nlm.nih.gov
Understanding the characteristics of cancer cells is essential for the development of
improved diagnosis and therapeutics. From a gene regulation perspective, the super …
improved diagnosis and therapeutics. From a gene regulation perspective, the super …
Application of titanium dioxide nanoparticles in photothermal and photodynamic therapy of cancer: An updated and comprehensive review
The usage of nanoparticles (NPs) in treating and diagnosing many diseases, especially
cancer, has been investigated in recent studies. The primary purpose of using …
cancer, has been investigated in recent studies. The primary purpose of using …
[HTML][HTML] Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer
M Boström, E Larsson - Nature communications, 2022 - nature.com
Cancer gene discovery is reliant on distinguishing driver mutations from a multitude of
passenger mutations in tumour genomes. While driver genes may be revealed based on …
passenger mutations in tumour genomes. While driver genes may be revealed based on …
[HTML][HTML] The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations
The characterization of immortalized canine osteosarcoma (OS) cell lines used for research
has historically been based on phenotypic features such as cellular morphology and …
has historically been based on phenotypic features such as cellular morphology and …